Yale Cancer Biology Institute Publications 2024

Black, EM., Ramírez Parrado, CA., Trier, I., Li, W., Joo, YK., Pichurin, J., Liu, Y., Kabeche, L. (Dec 30 2024) Chk2 sustains PLK1 activity in mitosis to ensure proper chromosome segregation.(Link is external) Nature Communications. doi: 10.1038/s41467-024-54922-7. PMID: 39737931

Mollaoglu G, Tepper A, Falcomatà C, Potak HT, Pia L, Amabile A, Mateus-Tique J, Rabinovich N, Park MD, LaMarche NM, Brody R, Browning L, Lin JR, Zamarin D, Sorger PK, Santagata S, Merad M, Baccarini A, Brown BD. Ovarian cancer-derived IL-4 promotes immunotherapy resistance.(Link is external) Cell. (2024 Dec 26) doi: 10.1016/j.cell.2024.10.006. Epub 2024 Oct 30.PMID: 39481380

Park MD, Le Berichel J, Hamon P, Wilk CM, Belabed M, Yatim N, Saffon A, Boumelha J, Falcomatà C, Tepper A, Hegde S, Mattiuz R, Soong BY, LaMarche NM, Rentzeperis F, Troncoso L, Halasz L, Hennequin C, Chin T, Chen EP, Reid AM, Su M, Cahn AR, Koekkoek LL, Venturini N, Wood-Isenberg S, D’souza D, Chen R, Dawson T, Nie K, Chen Z, Kim-Schulze S, Casanova-Acebes M, Swirski FK, Downward J, Vabret N, Brown BD, Marron TU, Merad M. Hematopoietic aging promotes cancer by fueling IL-1⍺-driven emergency myelopoiesis.(Link is external) Science. (2024 Oct 25) doi: 10.1126/science.adn0327. Epub 2024 Oct 25.PMID: 39236155

Joo YK, Ramirez C, Kabeche L. (2024 Oct 19) A TRilogy of ATR’s Non-Canonical Roles Throughout the Cell Cycle and Its Relation to Cancer.(Link is external) Cancers (Basel).  doi: 10.3390/cancers16203536. PMID: 39456630

Sogunro, A., Muzumdar, M. (2024) Keep It Moving: Physical Activity in the Prevention of Obesity-Driven Pancreatic Cancer.(Link is external) Cancer Research. doi: 10.1158/0008-5472.CAN-24-1474. PMID: 39279380

Wang, S., Di, Y., Yang, Y., Salovska, B., Li, W., Hu, L., Yin, J., Shao, W., Zhou, D., Cheng, J., Liu, D., Yang, H., Liu, Y. (2024) PTMoreR-enabled cross-species PTM mapping and comparative phosphoproteomics across mammals.(Link is external) Cell Reports Methods. doi: 10.1016/j.crmeth.2024.100859. PMID: 39255793

Mühlenbeck, H., Tsutsui, Y., Lemmon, M., Bender, K., Zipfel, C. (2024) Allosteric activation of the co-receptor BAK1 by the EFR receptor kinase initiates immune signaling.(Link is external) Elife.  doi: 10.7554/eLife.92110. PMID: 39028038

Edman, N., Phal, A., Redler, R., Schlichthaerle, T., Srivatsan, S., Ehnes, D., Etemadi, A., An, S., Favor, A., Li, Z., Praetorius, F., Gordon, M., Vincent, T., Marchiano, S., Blakely, L., Lin, C., Yang, W., Coventry, B., Hicks, D., Cao, L., Bethel, N., Heine, P., Murray, A., Gerben, S., Carter, L., Miranda, M., Negahdari, B., Lee, S., Trapnell, C., Zheng, Y., Murry, C., Schweppe, D., Freedman, B., Stewart, L., Ekiert, D., Schlessinger, J., Shendure, J., Bhabha, G., Ruohola-Baker, H., Baker, D. (2024) Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies.(Link is external) Cell. doi: 10.1016/j.cell.2024.05.025. PMID: 38861993

Bagchi, A., Stayrook, S., Xenaki, K., Starbird, C., Doulkeridou, S., El Khoulati, R., Roovers, R., Schmitz, K., van Bergen En Henegouwen, P., Ferguson, K. (2024) Structural insights into the role and targeting of EGFRvIII.(Link is external) Structure. doi: 10.1016/j.str.2024.05.018. PMID: 38908376

Cecchini, M., Salem, R., Robert, M., Czerniak, S., Blaha, O., Zelterman, D., Rajaei, M., Townsend, J., Cai, G., Chowdhury, S., Yugawa, D., Tseng, R., Mejia Arbelaez, C., Jiao, J., Shroyer, K., Thumar, J., Kortmansky, J., Zaheer, W., Fischbach, N., Persico, J., Stein, S., Khan, S., Cha, C., Billingsley, K., Kunstman, J., Johung, K., Wiess, C., Muzumdar, M., Spickard, E., Aushev, V., Laliotis, G., Jurdi, A., Liu, M., Escobar-Hoyos, L., Lacy, J. (2024) Perioperative Modified FOLFIRINOX for Resectable Pancreatic Cancer: A Nonrandomized Controlled Trial.(Link is external) JAMA Oncology. doi: 10.1001/jamaoncol.2024.1575. PMID: 38900452 

Rosenberger, G., Li, W., Turunen, M., He, J., Subramaniam, P.S., Pampou, S., Griffin, A.T., Karan, C., Kerwin, P., Murray, D., Honig, B., Liu, Y., Califano, A. (2024) Network-based elucidation of colon cancer drug resistance mechanisms by phosphoproteomic time-series analysis.(Link is external) Nature Communications. doi: 10.1038/s41467-024-47957-3. PMID: 38724493

Gui, Y., Fu, H., Palanza, Z., Tao, J., Lin, Y.H., Min, W., Qiao, Y., Bonin, C., Hargis, G., Wang, Y., Yang, P., Kreutzer, D.L., Wang, Y., Liu, Y., Yu, Y., Liu, Y., Zhou, D.. (2024) Fibroblast expression of transmembrane protein smoothened governs microenvironment characteristics after acute kidney injury.(Link is external) The Journal of Clinical Investigation. doi: 10.1172/JCI165836. PMID: 38713523 

Ke, S., Dang, F., Wang, L., Chen, J.Y., Naik, M.T., Li, W., Thavamani, A., Kim, N., Naik, N.M., Sui, H., Tang, W., Qiu, C., Koikawa, K., Batalini, F., Stern Gatof, E., Isaza, D.A., Patel, J.M., Wang, X., Clohessy, J.G., Heng,Y.J., Lahav, G., Liu, Y., Gray, N.S., Zhou, X.Z., Wei, W., Wulf, G.M., Lu, K.P.. (2024) Reciprocal antagonism of PIN1-APC/CCDH1 governs mitotic protein stability and cell cycle entry.(Link is external) Nature Communications. doi: 10.1038/s41467-024-47427-w. PMID: 38622115

Bellone, S., Jeong, K., Halle, M.K., Krakstad, C., McNamara, B., Greenman, M., Mutlu, L., Demirkiran, C., Hartwich, T.M.P., Yang-Hartwich, Y., Zipponi, M., Buza, N., Hui, P., Raspagliesi, F., Lopez, S., Paolini, B., Milione, M., Perrone, E., Scambia, G., Altwerger, G., Ravaggi, A., Bignotti, E., Huang, G.S., Andikyan, V., Clark, M., Ratner, E., Azodi, M., Schwartz, P.E., Quick, C.M., Angioli, R., Terranova, C., Zaidi, S., Nandi, S., Alexandrov, L.B., Siegel, E.R., Choi, J., Schlessinger, J., Santin, A.D. (2024) Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix.(Link is external) Proc Natl Acad Sci USA. doi:10.1073/pnas.2321898121. PMID: 38625939

Hu, Z., Chen, PH., Li, W., Krone, M., Zheng, S., Saarbach, J., Velasco, IU., Hines, J., Liu, Y., Crews, CM. (2024) EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling.(Link is external) Science Advances. doi: 10.1126/sciadv.adj7251 PMID: 38536914 

Luan, Y., Hu, J., Wang, Q., Wang, X., Li, W., Qu, R., Yang, C., Rajendran, BK., Zhou, H., Liu, P., Zhang, N., Shi, Y., Liu, Y., Tang, W., Lu, J., Wu, D. (2024) Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis.(Link is external) Cell Reports.  doi: 10.1016/j.celrep.2024.113934. PMID: 38461416

Liao, X., Li, W., Zhou, H., Rajendran, B., Li, A., Ren, J., Luan, Y., Calderwood, D., Turk, B., Tang, W., Liu, Y., Wu, D. (2024) The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells.(Link is external) Nature Communications. doi: 10.1038/s41467-024-44885-0. PMID: 38242867 

Liu, Q., Zhang, J., Guo, C., Wang, M., Wang, C., Yan, Y., Sun, L., Wang, D., Zhang, L., Yu, H., Hou, L., Wu, C., Zhu, Y., Jiang, G., Zhu, H., Zhou, Y., Fang, S., Zhang, T., Hu, L., Li, J., Liu, Y., Zhang, H., Zhang, B., Ding, L., Robles, AI., Rodriguez, H., Gao, D., Ji, H., Zhou, H., Zhang, P. (2024) Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies.(Link is external) Cell. doi: 10.1016/j.cell.2023.12.004. PMID: 38181741

Huang, X., Gan, Z., Cui, H., Lan, T., Liu, Y., Caron, E., Shao, W. (2024) The SysteMHC Atlas v2.0, an updated resource for mass spectrometry-based immunopeptidomics.(Link is external) Nucleic Acids Research. doi: 10.1093/nar/gkad1068. PMID: 38000392 

Mudumbi, K., Burns, E., Schodt, D., Petrova, Z., Kiyatkin, A., Kim, L., Mangiacapre, E., Ortiz-Caraveo, I., Rivera Ortiz, H., Hu, C., Ashtekar, K., Lidke, K., Lidke, D., Lemmon, M. (2024) Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes.(Link is external) Cell Reports. doi: 10.1016/j.celrep.2023.113603. PMID: 38117650

Walker, G., Brown, C., Ge, X., Kumar, S., Muzumdar, M., Gupta, K., Bhattacharyya, M. (2024) Oligomeric organization of membrane proteins from native membranes at nanoscale spatial and single-molecule resolution.(Link is external) Nature Nanotechnology. doi: 10.1038/s41565-023-01547-4. PMID: 38012273