Yale Cancer Biology Institute Publications 2022

Krimmer, S., Schlessinger, J. (2022) Unveiling molecular insights into the mechanism of activation of oncogenic phosphoinositide 3-kinase mutants. Proc. Natl. Acad. Sci. U.S.A. PMID: 36475945 DOI: 10.1073/pnas.2218237119
 
Wenxue Li, W., Salovska, B., Fornasiero, E., Liu, Y. (2022) Towards a hypothesis-free understanding of how Phosphorylation dynamically impacts protein turnover. Proteomics. PMID: 36422574 DOI: 10.1002/pmic.202100387
 
An, S., Anneken, A., Xi, Z., Choi, C., Schlessinger, J., Toomre, D. (2022) Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis. Proc. Natl. Acad. Sci. U.S.A. PMID: 36417441 DOI: 10.1073/pnas.2208947119
 
Black, E., Joo, Y., Kabeche, L. (2022) Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma. The Biochemical Journal. PMID: 36416754 DOI: 10.1042/BCJ20220461
 
van Alderwerelt van Rosenburgh, I., Lu, D., Grant, M., Stayrook, S., Phadke, M., Walther, Z., Goldberg, S., Politi, K., Lemmon, M., Ashtekar, K., Tsutsui, Y. (2022) Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations. Nature Communications. PMID: 36357385 DOI: 10.1038/s41467-022-34398-z
 
Henry, S., Liosi, M., Ippolito, J., Menges, F.,  Newton, A., Schlessinger, J., Jorgensen, W. (2022) Covalent Modification of the JH2 Domain of Janus Kinase 2ACS Medicinal Chemisrty Letters. PMID: 36385940 DOI: 10.1021/acsmedchemlett.2c00414
 
Park, J., Choi, J., Cao, L., Mohanty, J., Suzuki, Y., Park, A., Baker, D., Schlessinger, J., Lee, S. (2022) Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein. Cell Reports. PMID: 36288716 DOI: 10.1016/j.celrep.2022.111545
 
Perez-Pepe, M., Alarcón, C. (2022) An RNA link for METTL16 and DNA repair in PDAC. Nature Cancer. PMID: 36138137 DOI: 10.1038/s43018-022-00434-6
 
Sheetz, J., Lemmon M. (2022) Looking lively: emerging principles of pseudokinase signalingTrends in Biochemical Sciences. PMID 35585008 DOI: 10.1016/j.tibs.2022.04.011
 
Ba, Q., Hei, Y., Dighe, A., Li, W., Maziarz, J., Pak, I., Wang, S., Wagner, G., Liu, Y. (2022) Proteotype coevolution and quantitative diversity across 11 mammalian speciesScience Advances. PMID: 36083897 DOI: 10.1126/sciadv.abn0756
 

Cai, W., Chen, J., Chen, H., Wingrove, E., Kurley, S., Chan, L., Zhang, M., Arnal-Estape, A., Zhao, M., Balabaki, A., Li, W., Yu, X., Krop, E., Dou, Y., Liu, Y., Jin, J., Westbrook, T., Nguyen, D., Yan, Q. (2022) Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation. eLife PMID: 36043466 DOI: 10.7554/eLife.78163

Ma, X., Dighe, A., Maziarz, J., Neumann, E., Erkenbrack, E., Hei, Y., Liu, Y., Suhail, Y., Kshitiz, I., Levchenko, A., Wagner, G. (2022) Evolution of higher mesenchymal CD44 expression in the human lineage: A gene linked to cancer malignancy. Evolution, Medicine, and Public Health. PMID: 36148042 DOI: 10.1093/emph/eoac036

Liosi, M., Ippolito, J., Henry, S., Krimmer, S., Newton, A., Cutrona, K., Olivarez, R., Mohanty, J., Schlessinger, J., Jorgensen, W. (2022) Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain LigandsJournal of Medicinal Chemistry. PMID 35653642 DOI: 10.1021/acs.jmedchem.2c00283

Cao, L., Coventry, B., Goreshnik, I., Huang, B., Sheffler, W., Park, J., Jude, K., Marković, I., Kadam, R., Verschueren, K., Verstraete, K., Walsh, S., Bennett, N., Phal, A., Yang, A., Kozodoy, L., DeWitt, M., Picton, L., Miller, L., Strauch, E., DeBouver, N., Pires, A., Bera, A., Halabiya, S., Hammerson, B., Yang, W., Bernard, S., Stewart, L., Wilson, I., Ruohola-Baker, H., Schlessinger, J., Lee, S., Savvides, S., Garcia, K., David Baker, D. (2022) Design of protein-binding proteins from the target structure alone. Nature. PMID: 35332283 DOI: 10.1038/s41586-022-04654-9
 

Henry, S., Liosi, M., Ippolito, J., Cutrona, K., Krimmer, S., Newton, A., Schlessinger, J., Jorgensen, W. (2022) Conversion of a False Virtual Screen Hit into Selective JAK2 JH2 Domain Binders Using Convergent Design StrategiesACS Medicinal Chemistry Letters. PMID: 35586418 DOI: 10.1021/acsmedchemlett.2c00051

Ahmed, M., Kaur, N., Cheng, Q., Shanabrough, M., Tretiakov, E., Harkany, T., Horvath, T., Schlessinger, J. (2022) A Hypothalamic Pathway for Augmentor α-controlled Body Weight RegulationProc. Natl. Acad. Sci. U.S.A. PMID: 35412887 DOI: 10.1073/pnas.2200476119

Mastracci, TL., Apte, M., Amundadottir, LT., Alvarsson, A., Artandi, S., Bellin, MD., Bernal-Mizrachi, E., Caicedo, A., Campbell-Thompson, M., Cruz-Monserrate, Z., El Ouaamari, A., Gaulton, KJ., Geisz, A., Goodarzi, MO., Hara, M., Hull-Meichle, RL., Kleger, A., Klein, AP., Kopp, JL., Kulkarni, RN., Muzumdar, M., Naren, AP., Oakes, SA., Olesen, SS., Phelps, EA., Powers, AC., Stabler, CL., Tirkes, T., Whitcomb, DC., Yadav, D., Yong, J., Zaghloul, NA., Sander, M., Pandol, SJ. (2022) Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Pancreas. doi: 10.1097/MPA.0000000000002170. PMID: 37078927

Sheetz, J., Lemmon M., Tsutsui Y. (2022) Dynamics of protein kinases and pseudokinases by HDX-MSMethods in Enzymology. 667: 303-338. PMID 35525545 DOI: 10.1016/bs.mie.2022.03.037

Peng, L., Hu, Y., Mankowski, M., Ren, P., Chen, R., Wei, J., Zhao, M., Li, T., Tripler, T., Ye, L., Chow, R., Fang, Z., Wu, C., Dong, M., Cook, M., Wang, G., Clark, P., Nelson, B., Klein, D., Sutton, R., Diamond, M., Wilen, C., Xiong, Y., Chen, S. (2022) Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617Nature Communications. PMID: 35347138 PMCID: PMC8960874 DOI: 10.1038/s41467-022-29288-3

Liu, Y. (2022) A peptidoform based proteomic strategy for studying functions of post-translational modifications. Proteomics. PMID: 34878717 DOI: 10.1002/pmic.202100316
 

Hu, C., Leche, C., Kiyatkin A., Yu, Z., Stayrook, S., Ferguson, K.Lemmon, M. (2022) Glioblastoma mutations alter EGFR dimer structure to prevent ligand biasNature. 602: 518-522. PMID 35140400 DOI: 10.1038/s41586-021-04393-3