Current Lab Members
Our Lab comprises trainees who are undertaking critical research that drives our scientific inquiry and productivity. Current lab members include:
| Postdoc: | Associate Research Scientists: |
|---|---|
| Hengyi Li |
Tongqing Li Yueyue Wang |
Daryl Klein Lab
The Klein Laboratory at Yale’s Cancer Biology Institute explores the fundamental design principles regulating extracellular signaling relays to reprogram oncogenic pathways in cancer. Leveraging phage display as a discovery platform, the lab develops fully human antibodies that precisely target key oncogenes. Research in the Klein lab has been instrumental in decoding the structural and mechanistic rules governing diverse oncogenic receptors. The long-term vision of the lab is to use these insights as a strategic blueprint to exploit cancer vulnerabilities and advance targeted therapies.
Recent Publications
- ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells
- 317 ALK chimeric antigen receptor T cells cooperate with ALK inhibitors to target neuroblastoma cells with low target density
- Discovery of the First Pathogenic Human EPO Mutation Provides Mechanistic Insight into Cytokine Signaling