Yale Cancer Biology Institute Publications 2025

Di Y, Li W, Castellano JJ, Jin W, Modi JN, Salovska B, Khosroabadi D, Hu W, Taylor AM, Liu Y. Divergent proteome tolerance against gain and loss of chromosome arms. Molecular Cell (2025 Nov 20) doi: 10.1016/j.molcel.2025.10.023.PMID: 41270725

Faust HJ, Chang MH, Jonsson AH, Theisen E, LaMarche NM, Trim WV, Lynch L, Nigrovic PA, Brenner MB. Adipose tissue harbors pathogenic T cells in obesity that exacerbate inflammatory arthritis. The Journal of Experimental Medicine. (2025 Sep 1) doi: 10.1084/jem.20240677. PMID: 40622306

Liu M, Jin S, Agabiti SS, Jensen TB, Yang T, Radda JSD, Ruiz CF, Baldissera G, Rajaei M, Li FY, Townsend JP, Muzumdar MD, Wang S. Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. Nature Genetics. (2025 Aug 18) doi: 10.1038/s41588-025-02297-w. Online ahead of print.PMID: 40825871

Joo YK, Parrado CR, Li W, Yang R, Black E, Bleichert F, Liu Y, Kabeche L. The mitotic ATR-Chk1 pathway promotes CDK1 activity for faithful chromosome segregation. Cell Reports. (2025 Aug 26) doi: 10.1016/j.celrep.2025.116019 PMID: 40705605

Hetzel S, Hodis E, Torlai Triglia E, Kovacsovics A, Steinmann K, Gnirke A, Cui M, McQuaid D, Weigert R, Pohl G, Muzumdar MD, Leyvraz S, Keilholz U, Yaspo ML, Regev A, Kretzmer H, Smith ZD, Meissner A. Direct genetic transformation bypasses tumor-associated DNA methylation alterations. Genome Biology. (2025 Jul 17) doi: 10.1186/s13059-025-03650-2. PMID: 40676699

Delanne-Cuménal M, Defaye M, Delanne-Cuménal A, Ahmed M, Ho V, Abdullah NS, Alhassoun M, Svendsen K, Mager L, Schlessinger J, Hirota S, Altier C. Neuronal ALKAL2 and its ALK receptor contribute to the development of colitis-associated colorectal cancer. Proceedings  of the National Acadamy of Sciences of the USA. (2025 Jun 17) doi: 10.1073/pnas.2500632122. PMID: 40493183

Chen XL, Ojalill M, Jean C, Tancioni I, Jiang S, Boyer A, Ozmadenci D, Uryu S, Tarin D, Schlessinger J, Stupack DG, Schlaepfer DD. Inducible FAK loss but not FAK inhibition in endothelial cells of PYK2-null mice activates p53 tumor suppressor to prevent tumor growth. Molecular Biology of the Cell. (2025 Jun 1) doi: 10.1091/mbc.E24-12-0562. PMID: 40202821

Salovska B, Li W, Bernhardt OM, Germain PL, Wang Q, Gandhi T, Reiter L, Liu Y. A robust multiplex-DIA workflow profiles protein turnover regulations associated with cisplatin resistance and aneuploidy. Nature Communications. (2025 May 30) doi: 10.1038/s41467-025-60319-x.PMID: 40447611

Wang Y, Gao J, Xie W, Tang M, Chen X, Chen L, Chen H, Yang Z, Gao Q, Liu Y, Zhou H. Online Alkaline-pH Reversed-Phase Nanoelectrospray-Tandem Mass Spectrometry Complements Traditional Phosphoproteomic Analysis via Influencing Charge State Distribution of Phosphopeptides. Journal of Proteome Research. (2025 May 2) doi: 10.1021/acs.jproteome.4c01091. PMID: 40205994

Li T, Stayrook SE, Li W, Wang Y, Li H, Zhang J, Liu Y, Klein DE. Crystal structure of Isthmin-1 and reassessment of its functional role in pre-adipocyte signaling. Nature Communications. (2025 Apr 15) doi: 10.1038/s41467-025-58828-w. PMID: 40234450

Chen JF, Xu P, Cai WL, Chen H, Wingrove E, Shi X, Li W, Biancon G, Zhang M, Balabaki A, Krop ED, Asare E, Zhang Y, Yin M, Tebaldi T, Meier JL, Westbrook TF, Halene S, Liu Y, Shen H, Nguyen DX, Yan Q. An in vivo screen identifies NAT10 as a master regulator of brain metastasis. Science Advances. (2025 Mar 28) doi: 10.1126/sciadv.ads6021. PMID: 40138393

Li W, Dasgupta A, Yang K, Wang S, Hemandhar-Kumar N, Chepyala SR, Yarbro JM, Hu Z, Salovska B, Fornasiero EF, Peng J, Liu Y. Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions. Cell. (2025 Mar 14) doi: 10.1016/j.cell.2025.02.021 PMID: 40118046

Belabed M, Park MD, Blouin CM, Balan S, Moon CY, Freed G, Quijada-Álamo M, Peros A, Mattiuz R, Reid AM, Yatim N, Boumelha J, Azimi CS, LaMarche NM, Troncoso L, Amabile A, Le Berichel J, Chen ST, Wilk CM, Brown BD, Radford KJ, Ghosh S, Rothlin CV, Yvan-Charvet L, Marron TU, Puleston DJ, Wagenblast E, Bhardwaj N, Lamaze C, Merad M. Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer. Nature Immunology. (2025 Feb 26) doi: 10.1038/s41590-024-02065-8. Epub 2025 Jan 21.PMID: 39838105

Liu, Y. Mass spectrometry-based mapping of plasma protein QTLs in children and adolescents. Nature Genetics. (2025 Feb 19). doi: 10.1038/s41588-025-02088-3. PMID: 39972213

Yarbro, JM., Han, X., Dasgupta, A., Yang, K., Liu, D., Shrestha, HK., Zaman, M., Wang, Z., Yu, K., Lee, DG., Vanderwall, D., Niu, M., Sun, H., Xie, B., Chen, PC., Jiao, Y., Zhang, X., Wu, Z., Chepyala, SR., Fu, Y., Li, Y., Yuan, ZF., Wang, X., Poudel, S., Vagnerova, B., He, Q., Tang, A., Ronaldson, PT., Chang, R., Yu, G., Liu, Y., Peng, J. Human and mouse proteomics reveals the shared pathways in Alzheimer’s disease and delayed protein turnover in the amyloidome. Nature Communications. (2025 Feb 11) doi: 10.1038/s41467-025-56853-3. PMID: 39934151

Searle, BC., Chazarin, B., Collins, BC., Kundu, DJ., Huang, S., Lin, Q., Liu, Y., Low, TY., Saba, J., Guo, T., Palmisano, G., Fert-Bober, J. Advancing Scientific Communication in Proteomics. Journal of Proteome Research. (2025 Feb 7) doi: 10.1021/acs.jproteome.4c01098. PMID: 39916559

Brown, TJ, Pichurin, J, Parrado, CR, Kabeche, L, Baserga, SJ. A role for the kinetochore protein, NUF2, in ribosome biogenesis. Molecular Biology of the Cell. (2025 Feb 1) doi: 10.1091/mbc.E24-08-0337. PMID: 39705402


Zhang, J., Tsutsui, Y., Li, H., Li, T., Wang, Y., Laraki, S., Alarcon-Frias, S., Stayrook, SE., Klein, DE. Structural basis for the interaction between the Drosophila RTK Sevenless (dROS1) and the GPCR BOSS. Nature Communications. (2025 Jan 18) doi: 10.1038/s41467-025-55943-6.PMID: 39827240

Wang, Y., Zhang, Y., Li, W., Salovska, B., Zhang, J., Li, T., Li, H., Liu, Y., Kaczmarek, LK., Pusztai, L., Klein, DE. GABAA receptor π forms channels that stimulate ERK through a G-protein-dependent pathway. Molecular Cell. (2025 Jan 2) doi: 10.1016/j.molcel.2024.11.016. PMID: 39642883