Collaborating with Novelna, Inc. and across the CIRCLE program, the Yale team, which includes Ruslan Medzhitov, Sterling Professor of Immunobiology, and John Tsang, Anthony N. Brady Professor of Immunobiology and of Biomedical Engineering, will contribute advanced computational and experimental approaches to help develop next-generation “digital twin” models capable of predicting how an individual patient’s immune system will evolve in response to injury, infection, and treatment.
In parallel, researchers will establish experimental platforms using human immune cells and microfluidic technologies to test and validate model predictions under precisely controlled conditions.
The CIRCLE program aims to reimagine the way clinicians care for the 4.6 million Americans admitted to intensive care units (ICUs) each year. Many who come through intensive care struggle with long-term complications such as post-ICU syndrome, a collection of debilitating physical and cognitive symptoms that can persist for months or years after discharge.